Clinical Trials

Phase II study of autologus human dermal fibroblasts for the treatment of moderate to severe nasolabial fold wrinkles in adults 


Collaborated with Taipei Medical University

Skin aging is characterized by the loss of extracellular matrix such as collagen and elastin in the connective tissue, leading to wrinkles. Injection of fibroblasts increases collagen formation, which in turn increases skin collagen thickness and density and improve the degree of wrinkles and does not cause inflammation. In this clinical trial, the ear- skin samples are obtained, and the fibroblasts are isolated and cultured in Maria Von’s laboratory. The cells containing 1.6-2.4 x 107 cells/ml are administered to the subject every two weeks, for a total of three times. Subjects nasolabial fold wrinkles are evaluated for improvement.


Phase I study of autologous transplantation of cultured fibroblasts for wound, depressed scars and other pathological skin defects filling and replacement 


Collaborated with Taipei Medical University  (The trial has ended)

This technology of autologous cultured cell transplantation is novel on the fact that it is patient’s self material, therefore, there is no risk of allergic reactions, rejection or transmission of infectious diseases. Comparing with allogeneic filling materials (as hyaluronic acid or animal collagen) its safety is much higher and less likely to lose its function by being absorbed or rejected. This technology can be useful not only on the clinical treatments of depressive scars, but also on the burns, post traumatic wounds, diabetic ulcers and congenital or acquired atrophic skin disorders.



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