Preclinical Developments

Assessment of the efficacy of skin mesenchymal stem cells in the treatment of mood disorders ▍

Cooperating with the National Taiwan Normal University: To study the effects of skin mesenchymal stem cells in a mouse model of depression.

 

Neuroinflammation and increase in cellular oxidative stress are one of the causes of the development of mood disorders (depression). This preclinical animal test mainly treats melancholic mice with mesenchymal stem cells, suppresses inflammation and eliminates the imbalance of cellular oxidative stress, and evaluates whether the mesenchymal stem cells have the effect of improving symptoms in depression animal models.

 

Therapeutic effect of multipotent stromal cells from skin in non-obese diabetic mice  

To study the therapeutic effect of multi potent stromal cells on non-obese diabetic mice: collaborated with National Defense Medical Center

Type 1 diabetes results from the destruction of insulin producing β cells caused by autoimmune disease. In this preclinical animal model experiment, skin-derived mesenchymal stem cells are used to treat non-obese diabetic mice, and the therapeutic effects of skin-derived mesenchymal stem cells on type 1 diabetes are evaluated.

 

 

Study of thermoreversible hydrogel for articular cartilage repair  

To study thermoreversible hydrogel for articular cartilage repair: collaborated with National Tsing Hua University

Temperature sensitive polymer water gel (Pluronic) in recent years began to be applied in the field of drug delivery and medical materials, which peptide-modified Pluronic as a scaffold can also be used in tissue engineering. In this preclinical animal trial, the repair of articular cartilage defects was performed primarily with Pluronic to assess the feasibility of this material as a medical device.

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